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Next-Gen Proteomics: High-Fidelity Enrichment, New Mass Spec, and Single-Molecule Fingerprinting

Mass spectrometry (MS) has long been a bedrock tool in proteomics investigations, with liquid chromatography mass spectrometry (LC-MS) especially key in analyzing the presence, identity, and quantity of proteins in a complex sample. But the expanding scope of proteomics research requires higher resolution than traditional MS techniques can offer, and as such, new sample preparation techniques that supplement and enhance MS workflows as well as novel MS approaches constitute a large swath of the next-gen proteomics market.

The Need and Opportunity for Next-Generation Proteomics Tools

Since the term “proteome” first appeared in the scientific literature in 1995, interest in proteomics research and its use in applications like drug discovery, tumor characterization, and disease biomarker identification has exploded. With that growth has come a need for new approaches to catalog and study the proteome, as conventional techniques often fall short in accomplishing the specificity, sensitivity, and throughput required by ambitious emerging research efforts and applications.

M&A Highlights August 29–November 14

Washington, DC-based conglomerate Danaher will separate its Environmental & Applied Solutions segment into a new, independent, publicly traded company. The new company will contain Danaher’s Water Quality and Product Identification businesses, including Hach, a manufacturer of water quality testing instruments and reagents, and X-rite, a manufacturer of spectrophotometers and other color analysis products. After the separation, which is expected to be completed in the fourth quarter of 2023, Danaher will be composed of its Life Sciences and Diagnostics segments, including companies like Beckman Coulter, Leica Biosystems, and Integrated DNA Technologies.

With Pipette Tip Washing Machines, Grenova Is on a Mission to Make Labs Greener

Walk into any life sciences lab, and you’re bound to see beakers or other containers filled with discarded pipette tips on each bench top. Between tips, tubes, and plates, research runs on single-use plastic. Recent plastics price spikes, manufacturing shortages, and supply-chain disruptions have hobbled labs, and COVID testing and treatment research have amplified need for these items. For example, a lab technician might use ten pipette tips to run one coronavirus test, between handling the sample, the test reagents, and setting up the PCR reaction.

“Stormy Waters” Ahead Projected in IMF’s October World Economic Outlook

As global inflation remains the highest it’s been in several decades, about one-third of the global economy is expected to contract this year or next. In its October 2022 World Economic Outlook (WEO): Countering the Cost-of-Living Crisis, the International Monetary Fund (IMF) projects global growth will remain at 3.2% in 2022, unchanged from July’s forecast, and will drop to 2.7% in 2023, a 0.2% downgrade from that projection. Global inflation is expected to rise to 8.8% in 2022 but decline to 6.5% in 2023 and to 4.1% in 2024.

ACD/Labs Software Makes Analytical Data Seamless

Across an R&D lab, there’s a torrent of data and an ever-expanding number of workflows to keep in check. And volume is not the only challenge; each analysis may require different data formats or sometimes even multiple formats within a technique. Keeping track of such data manually can be time consuming and prone to errors, and standard spreadsheet software like Microsoft Excel or Google Sheets is not equipped to understand and display chemical formulas or structures, which are essential components of processes like drug development.

M&A Highlights July 1–August 9

Agilent Technologies has acquired Polymer Standards Service (PSS), which provides hardware and software solutions for polymer characterization. The acquisition of PSS, which is based in Mainz, Germany, “will add key technology to Agilent’s gel permeation chromatography and size exclusion chromatography offerings,” said Jacob Thaysen, senior vice president, Agilent.

IMF’s Global Economic Outlook Remains “Gloomy” and Uncertain

As new risks spill into an economy already weakened by the COVID-19 pandemic, the International Monetary Fund (IMF) forecasts global growth to continue to slow in 2022. In its July 2022 World Economic Outlook (WEO) Update: Gloomy and More Uncertain, an update to its yearly WEO released in April, the IMF predicts growth to slow to 3.2% in 2022, revising its April forecast of 3.6% and down from 6.1% in 2021.