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Q2 2024 Market Report: Inching Toward Growth

For leading international publicly held life science and analytical instrument companies, the second quarter of 2024 showed signs of improvement, with some firms reporting results slightly better than expected.

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IMF Projects Converging Growth in July’s World Economic Outlook Update

In its July 2024 World Economic Outlook (WEO) Update: The Global Economy in a Sticky Spot, the International Monetary Fund (IMF) has stuck with its global growth estimates as forecast in April’s WEO: Steady but Slow: Resilience Amid Divergence, with GDP predicted to gain 3.2% in 2024 and 3.3% in 2025. Activity varied across economies at the beginning of 2024, with many countries experiencing higher growth than had been expected, owing in part to increased world trade, attributable to strong technology exports from Asia. Domestic consumption ramped up in China, and the services sector improved in Europe. In contrast, curbed consumption and negative net trade slowed US growth, which had been outperforming expectations. In Japan, a New Year’s Day earthquake caused a short period of supply disruption and the shutdown of automobile production. 

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Q1 2024 Market Report: Powering Through, Awaiting the Upturn

As a challenging macroeconomic environment continues, leading international publicly held life science and analytical companies reported revenue for the first quarter of 2024 that was generally down in the low to high single digits, against tough comparisons of strong growth a year ago. This was all roughly as expected. 

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Industry Growth: Q1 2024

For Q1 2024, the Lab Analytical and Life Science markets continued to contract owing to softness in CapEx, adjusting for heightened demand over the past few years. Many of the of the largest companies/divisions in the industry experienced notable declines in revenues, with Thermo Fisher Life Science Solutions, Agilent, and Merck Science and Lab Solutions down 12.5%, 8.4%, and 8.3%, respectively. Conversely, the Process Analytical market experienced high single-digit growth in the first quarter. As expected, demand from the pharma/bio and chemicals industries fell, while the semiconductor and petrochemicals markets experienced strong growth.

…markets appear to be bottoming out and are expected to return to positive growth in the near future.

The Lab Analytical and Life Science Tools markets appear to be bottoming out and are expected to return to positive growth in the near future. However, as a result of geopolitical conflicts (e.g., Ukraine-Russia, Israel-Hamas, South China Sea), upcoming 2024 elections, and uncertainties surrounding public funding and research investment, the path to recovery may be a bit longer than anticipated. The ISM Manufacturing Purchasing Managers Index remains below 50 (May: 48.7, Apr: 49.2), signaling more contraction for Q2 2024.

About TDA’s Industry Growth Indices

TDA’s Industry Growth Indices are available on its data dashboard. Members can easily benchmark quarterly growth across three broad markets: Lab Analytical, Life Science Tools, and Process Analytical Instrumentation.

The Lab Analytical Index tracks global demand for laboratory products that are used for analytical testing. The Life Science Tools Index measures global consumption of life science research products that support workflows for DNA, protein and cellular analysis. Process Analytical Index monitors global demand for process analytical instruments (PAI).

The quarterly growth indices are based on import/export data from major manufacturing sectors: pharmaceuticals, chemicals, petrochemicals, semiconductor and other industries. These sectors represent the primary consumers of laboratory products, life science tools, and process instrumentation. The indices’ algorithms incorporate shipments and values of key product segments such as analytical instrumentation, process control, reagents, and cell culture products.

If you have any questions, please feel free to contact TDA.

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PAI 2024: The Process Analytical Instrument Market Report

PAI/2024 is the latest edition of the PAI report series, providing worldwide product forecasts for 2022–2028 (by year). The product forecasts are shown by major end-user market segment and by geographic region. The report identifies the leading suppliers in each of the technology categories, including liquid analyzers, photometers/spectroscopy, oxygen, gas chromatography, mass spectrometers, moisture analyzers, advanced analyzers, and other continuous process analyzers.

In 2023, the process analytical instruments (PAI) market totaled $5.9 billion and is experiencing robust growth, fueled by new hydrocarbon processing projects, particularly in the Asia-Pacific region. Sustainability, carbon capture, and alternative fuels continue to be industry drivers for analyzer companies. Geopolitical uncertainties (e.g., Ukraine-Russia, Israel-Palestine, and South China Sea conflicts) have caused supply-chain disruptions, forcing companies to rethink their global strategies.

The impact of the retiring baby boom generation, which represents less than 10% of the workforce, is changing the dynamic of the industry. With about 2%–3% of the workforce retiring each year (and, presumably, most of those retiring are baby boomers), the industry is losing unprecedented knowledge and experience, some of which is not being replaced. Boomer characteristics, such as brand loyalty and change resistance, are being lost as well, which might be good news to innovative analyzer companies, particularly as the next generations (GenX and millennials) tend to favor high technology. It seems purchasers of process analytical instruments maintain a cautious approach for existing applications and workflows but are also embracing new technologies and next-generation tools, including AI-based soft sensors to help predict product quality–related parameters. The industry historically has been slow to adopt new technologies, but change is happening, and it is happening at an accelerated pace. 

Our continuing goal is to illustrate and quantify the total market opportunity (total addressable market – TAM, serviceable addressable market, SAM, and serviceable obtainable market, SOM. In addition, TDA offers consulting services to clients with specific requirements on a private basis. Our top-down, strategic services include acquisition and divestiture support (i.e., due diligence), diversification measures and opportunity analyses, and strategy development.

The PAI/2024 Report (published April 2024) is available for purchase. Please contact Glenn Cudiamat, President & CEO, TDA (glenn@tdaresearch.com) for more information. 

US Federal R&D Funding Cut 3% for 2024

Nearly seven months after the start of the US fiscal year (FY) 2024, the US federal government finally has a budget, with the second set of twelve appropriations bills signed into law by President Biden on March 23. These annual bills, which fund the government through September 30, 2024, provide $194.3 for research and development (R&D) funding, a cut of about $5 billion (2.7%) compared to last year, when a substantial increase of 10% had been appropriated. These cuts occurred following spending limits imposed by the Fiscal Responsibility Act of 2023.

In this context, most agencies conducting R&D had their budgets cut for fiscal year 2024. The National Science Foundation (NSF) and the National Institute of Standards and Technology (NIST) both saw their funding lowered by 8%, leaving NSF’s budget at $9.87 billion and NIST’s at $1.26 billion. These cuts follow big increases last year, however, when NSF’s budget went up 12% and NIST received a 23% increase, both largely driven by the CHIPS and Science Act, passed in 2022 to fund semiconductor manufacturing and research in the United States. 

Critically, support for the National Institutes of Health (NIH), the largest overall funder of US scientific research, is essentially flat, down less than 1%, to $48.5 billion. Most of the 27 institutes and centers within NIH have flat budgets for 2024, with exceptions for research on mental health and Alzheimer’s disease, up $75 million and $100 million, respectively. 

Within the NIH, the National Cancer Institute (NCI) gained $120 million for research grants. However, the additional $216 million that NCI was receiving from the Cancer Moonshot ended last year; the result is that the total NCI budget for FY2024 is down $96 million compared to 2023. The budget for National Institute of Allergy and Infectious Disease (NIAID) remains flat at $6.6 billion. 

The Advanced Research Projects Agency for Health (ARPA-H), created in March 2022 to support high-potential, high-impact biomedical and health research, was allocated $1.5 billion, the same as in 2023, although President Biden had requested a $1 billion increase. One exciting new initiative just launched by ARPA-H is the Lymphatic Imaging, Genomics, and pHenotyping Technologies (LIGHT) program, which will pursue comprehensive diagnostic tools for detecting lymphatic dysfunction.

Another bright note was the 1.7% increase Congress to the Department of Energy (DOE)’s Office of Science. With a 2024 budget of $8.24 billion, the Office, which stewards 10 of the country’s national laboratories, is the largest source of physical science research funding in the US. It is also the lead federal agency supporting fundamental energy production research—critical for the transition to green energy. 

The Science and Technology arm of the Environmental Protection Agency (EPA) had its budget reduced $44 million, or 5.5%, to $758 million, while funding for the EPA as a whole was slashed 10.3%—the largest cut to agencies conducting R&D. Nevertheless, the fight over the 2024 budget fended off Republican plans to roll back climate and clean energy programs created by the Inflation Reduction Act of 2022.

Smaller budgets for some US government agencies that fund science research will likely somewhat depress academic and government sector opportunities for analytical instrument companies this year. However, the massive investments championed by the Biden Administration through the 2022 Inflation Reduction Act and the CHIPS Act will continue, with much of the actual spending still to take place. Currently, for example, the Department of Commerce is working to establish the National Semiconductor Technology Center (NSTC), which will support semiconductor R&D and manufacturing and drive demand for instrumentation and tools for both research and industrial end uses. Similarly, the new CHIPS R&D Metrology Program, run through NIST, will seek to strengthen the US semiconductor industry through advanced measurement, standardization, modeling, and simulation. 

Likewise, ongoing strong funding for NIH also means that health and disease research will continue unabated, maintaining need for life sciences instrumentation and related tools, such as mass spectrometers, proteomics and multiomics tools, advanced software, laboratory automation, chromatographs, spectrometers, NMR, and microscopy. 

Q4 2023 and Full Year 2023 Market Report: Managing Through Challenging Times

Facing a challenging macroeconomic environment, most leading international publicly held life science and analytical instrument companies reported sales declines in the mid-single digits for the fourth quarter of 2023 and drops in the low single-digits for the full year—all against tough comparisons of strong growth from the previous year. In short, 2023 was a year when the pandemic tailwinds became headwinds. 

Bruker stood out as an exception, reporting organic revenue gains around 15% for both the quarter and full year. The company saw organic growth in the mid teens in all divisions, with NMR growth across biopharma, academia and government, industrial research, and applied markets and mass spectrometry (MS) and optical spectroscopy gains driven by life sciences. 

Shimadzu was also an exception. Organic revenue grew 6% for the quarter for its analytical instrumentation business, with sales of “key models”—liquid and gas chromatography (LC and GC) and MS— up 12% in a fourth consecutive quarter of double-digit growth, driven mainly from pharmaceutical and academia for LC, by academia for MS, and by new energy development for GC. Shimadzu’s spectroscopy sales were down 1%, and the company felt the post-pandemic decline in MALDI and PCR.

Pharma/Biopharma and China—the Biggest Weights on Growth

The biggest sector drag on growth was the bio/pharmaceutical industry, with sales falling in the mid-single digits  as intense pandemic-era investments normalized following robust growth a year ago. 

Declines in China weighed the most heavily on this sector. For example, Agilent’s biopharmaceutical sales for the quarter fell 12%, versus 11% growth a year ago, but ex-China, the sector grew by low single digits. Similarly, full-year China revenues for Waters, heavily weighted in pharma, fell more than 20%, creating a 5% headwind to total growth; ex-China, Waters’s sales grew by high-single-digits. 

Shimadzu was able to balance pharma and CRO declines in China with MS sales for academic and clinical use. The company also sees positive future signs in traditional Chinese medicine, the preparation of the 2025 edition of the Chinese pharmacopeia, and new regulations requiring clinical use of MS in hospitals of a certain scale. 

On a positive note, stabilization and even signs of growth are seen in the emerging biotech sector, which has been facing a challenging funding market.

PFAS and Batteries Propel Applied Markets

Applied markets held steady in the quarter and overall for 2023, with companies expressing optimism for future growth driven by PFAS analysis and renewable energies, particularly batteries. Food and environmental applications account for about 11% of the laboratory instrumentation market, while industrial applications (chemicals, energy, plastics, metals/minerals, etc.) account for about 16%.

Shimadzu saw growth in both GC and non-destructive testing for new energy development, particularly in Japan and China. Battery applications revenues at Waters are now ten times above 2019 levels. Thermo Fisher, which showed low single-digit growth in industrial and applied markets for both the quarter and the year, opened a customer experience center for battery manufacturing in Seoul, Korea.

New regulations worldwide continue to drive PFAS testing, currently focused on water but expanding to food, tissue samples, soil, sewage, and industrial effluent streams. Waters expects PFAS testing to contribute an additional 30 basis points to revenue growth for the foreseeable future. 

Veralto, the environmental and applied solutions company spun out of Danaher last year, reported 2% core sales growth for its water quality business versus 9.5% a year ago, with Chinese municipal budgets continuing to be impacted by government funding cuts; full year sales were up 5%. 

Academic and government sales, which generally contribute about 30% of the lab market, were positive. The stability of academic funding and government laboratory activity were reflected in Agilent’s and Thermo Fisher’s growth in the low- to mid-single digits for the academic and government markets for the quarter and, in Thermo’s case, high-single digits for the full year. For Waters, this sector fell 9% in the quarter, dragged down by a 40% decline in China after government stimulus ended in the second quarter, but grew by mid-teens for the year.

Challenges in Life Sciences Research and Diagnostics

As in biopharma, producing growth in life sciences research and diagnostics compared to strong numbers from a year ago was also a challenge.

Core revenue for Agilent’s Diagnostics and Genomics Group fell 6% while the Life Sciences and Applied Markets Group dropped 11%, against 10% growth last year. At Thermo Fisher, fourth quarter revenue for diagnostics and healthcare declined in the high teens and was 30% lower for the full year. At Danaher, life sciences core revenue was down 4%, and the life sciences instruments business declined mid-single digits. 

Danaher’s clinical diagnostics business, however, delivered high-single-digit core revenue growth, led by Beckman Coulter Diagnostics with double-digit gains in both instruments and consumables.

Illumina also grew Q4 core revenue, at 4%, with 352 shipments of the new NovaSeq X high-throughput sequencing system. Annual revenues were flat, however, amid the general constraints affecting the laboratory space overall.

Bruker, as outlined above, stood out with large gains.

2024 Outlook: Expecting a Tough Year Ahead

Looking ahead to 2024, the industry expects another challenging year. Sales will start slowly as customers continue to exhibit spending caution, followed by slow normalization in the second half of the year as budgets open up and prior-year comparisons become easier, particularly in China, given high first-half growth numbers last year driven by the China loan program. Post-pandemic biopharma destocking conditions should improve, with the drawing down happening fastest in Western Europe and North America. 

Overall, companies are forecasting organic sales growth in 2024 in the very low-single digits, but it is unclear whether that will be on the negative or positive side. Bruker, an exception, anticipates organic growth of 5% to 7% for 2024.

2024 TDA Instrument Industry Outlook Report Now Available

Each successive year since the coronavirus pandemic, it seems we wonder if this will be the year in which conditions return to some approximation of normal following the economic turmoil COVID-19 caused. Although each year so far, the answer has been no, it appears that each year has been marked by incremental shifts toward equilibrium. In 2023, supply chains, shipping costs, and, delivery times largely returned to their prepandemic statuses, and a global recession seems to have been averted. However, high inflation, while falling, continues to contribute to weakened consumer sentiment, and fiscal policy in some economies still reflects the detrimental effects of the pandemic.  

The lab and analytical instruments market has undergone a somewhat different experience—the industry, as a whole, initially maintained its positive growth trajectory during the pandemic, although individual technology segments were subject to vastly different levels of demand. In 2021, several of the segments that were adversely affected rebounded, while those that benefited from the health emergency continued to flourish. Demand has since continued to be influenced by the purchasing early in the pandemic. 

For 2023, we have observed reduced or negative growth across industry segments, following a year with slowed or negative growth in almost all technology categories (although a few segments experienced double-digit growth). Demand from other/applied customers dropped the most as clinical/diagnostics needs receded substantially along with end the COVID-19 health emergency. All major regional markets also declined.

Download TDA’s 2024 Industry Outlook report in full to continue reading.

TDA’s 2023 Outlook Mid-Year Update Available

The major factors shaping economic conditions for 2023 are similar to those in the year prior with recovery—from the COVID-19 pandemic and Russia’s invasion of Ukraine—on the distant horizon. Persistent inflation continues to reduce growth in the analytical instruments industry as customers have less cash available to spend. Currency effects also further reduce the purchasing power of many customers against the stronger US dollar.

With the return of labs to pre- pandemic operations, the products and technologies that experienced record surges in demand in response to the pandemic, such as genetic analysis tools and cold-storage equipment, will suffer the largest drops in demand. In light of these conditions, we have adjusted our expectation of growth for the analytical instrument industry in 2023 downward to a market size of $68.5 billion.

Download TDA’s 2023 Outlook Mid-Year Update report to continue reading.

IMF Cites Slight Improvement in July’s World Economic Outlook Update

Despite the May declaration by the World Health Organization (WHO) that COVID-19 is no longer a global health emergency and the resolution of many supply chain and shipping problems, global recovery from the COVID-19 pandemic and Russia’s invasion of Ukraine has slowed, according to the International Monetary Fund (IMF) in its July 2023 World Economic Outlook (WEO) Update: Near-Term Resilience, Persistent Challenges. The increases in central bank policy rates enacted to combat inflation have hindered economic activity, resulting in weak global growth. But growth estimates are slightly higher than predicted in April’s WEO on account of strength of the services sector in the first quarter of 2023. The most recent publication projects that global growth will drop from 3.5% in 2022 to 3.0% in 2023 and remain at 3.0% in 2024. Headline inflation is predicted to decline to from 8.7% in 2022 to 6.8% in 2023 and 5.2% in 2024.

Although the consumption of services increased early in 2023, other sectors, including manufacturing, experienced weakness. According to the IMF, the slowdown of industrial production in advanced economies has suppressed global trade and manufacturing in emerging markets. The report predicts that world trade growth will drop from 5.2% in 2022 to 2.0% in 2023 and then rise to 3.7% in 2024.

Corresponding to the decline in economic activity, oil prices are expected to decrease by about 21% in 2023 after increasing 39% in 2022. Lower commodity prices worldwide along with tightening monetary policy will drive the disinflation in 2023.

 

The IMF predicts 93% of the world’s advanced economies will experience declining growth of 1.5% in 2023 (down from 2.7%). In the US, an increase in consumption in 2023 is not anticipated to last, as savings have declined, and the Federal Reserve is expected to again raise interest rates. In Europe, strength in services and tourism has been offset by weakness in manufacturing in Germany. Pent-up demand in Japan, however, will result in growth of 1.4% in 2023, up from 1.0% in 2022.

In general, developing economies are expected to make a stronger showing, averaging 4.0% growth in 2023 and 4.1% in 2024. This growth will vary by region, however, with about 61% of the economies growing faster in 2023. Emerging and developing Asia is expected to grow 5.3% in 2023 and then dip to 5.0% in 2024. China will hit 5.2% in 2023 then drop to 4.5% in 2024 (stronger-than-expected net exports have helped to offset weakened investment resulting from the real estate downturn this year). Strong domestic investment in India has prompted a projection of 6.1% growth in 2023.

The analytical instruments industry continues to experience ups and downs of global economic recovery. The recovery of supply chains has improved prospects for orders and delivery of products. On the other hand, persistent inflation is a consideration in laboratories’ budgets, likely limiting their ability to purchase instruments. However, according to the US Energy Information Administration, US crude oil production is expected to reach record highs in 2023, which will drive increased demand for materials analysis and process analytical instrumentation products.